منابع مشابه
Are metacaspases caspases?
The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence that metacaspases lack caspase activity and that they are not responsible for the caspaselike acti...
متن کاملType I Metacaspases Control Cell Death
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متن کاملCaspases
U ncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lym-phoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphad-enopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the lpr and gld phenotypes led to a satisfying...
متن کاملDeath without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
متن کاملMetacaspase activity of Arabidopsis thaliana is regulated by S-nitrosylation of a critical cysteine residue.
Nitric oxide (NO) regulates a number of signaling functions in both animals and plants under several physiological and pathophysiological conditions. S-Nitrosylation linking a nitrosothiol on cysteine residues mediates NO signaling functions of a broad spectrum of mammalian proteins, including caspases, the main effectors of apoptosis. Metacaspases are suggested to be the ancestors of metazoan ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200705193